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The efficacy of treatment with albendazole

1991; Elsevier BV; Volume: 50; Issue: 2 Linguagem: Inglês

10.1016/0001-706x(91)90003-3

1873-6254

K. Hanjeet, Richard Mathias,

Parasites and Host Interactions

Albendazole, a benzimidazole derivative, was administered as a single dose of either 400 mg or 600 mg to two groups to ascertain the efficacy, tolerance and safety of the regimens. At a dose of 400 mg, a cure rate 3536 (97%) against Ascaris was found. At 600 mg, the cure rate was 2130 (70%), significantly lower than the 400 mg rate. Against Trichuris, albendazole at 400 mg had a cure rate of 2148 (44%), at 600 mg there was a cure rate of 2943 (67%). Mild side effects were noted in 7 individuals. Whether the moderate increase in efficacy against Trichuris and the loss of efficacy against Ascaris improves the cost:benefit ratio must be left to the prescriber of the drug.