Portal de Periódicos da CAPES

Ultrastructural changes in rat liver cells following a single oral dose of TCDD.

1973; National Institute of Environmental Health Sciences; Volume: 5; Linguagem: Inglês

10.1289/ehp.7305141

1552-9924

B A Fowler, George W. Lucier, H. W. Brown, Otelia S. McDaniel,

Pharmacological Effects and Assays

Research ArticleOpen AccessUltrastructural changes in rat liver cells following a single oral dose of TCDD. B A Fowler, G W Lucier, H W Brown, and O S McDaniel B A Fowler , G W Lucier , H W Brown , and O S McDaniel Published:1 September 1973https://doi.org/10.1289/ehp.7305141Cited by:22AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit FiguresReferencesRelatedDetailsCited by Gagliano-Jucá T, Tang E, Bhasin S, Pencina K, Anderson S, Jara H, Li Z, Melamud K, Coleman S, Aakil A, Almeida R, Huang G, Travison T, Storer T and Basaria S (2017) Effects of testosterone administration (and its 5-alpha-reduction) on parenchymal organ volumes in healthy young men: findings from a dose-response trial, Andrology, 10.1111/andr.12392, 5:5, (889-897), Online publication date: 1-Sep-2017. Rosińczuk J and Całkosiński I (2015) Effect of tocopherol and acetylsalicylic acid on the biochemical indices of blood in dioxin-exposed rats, Environmental Toxicology and Pharmacology, 10.1016/j.etap.2015.04.017, 40:1, (1-11), Online publication date: 1-Jul-2015. Całkosiński I, Rosińczuk-Tonderys J, Bronowicka-Szydełko A, Dzierzba K, Bazan J, Dobrzyński M, Majda J and Gamian A (2013) Effect of tocopherol on biochemical blood parameters in pleuritis-induced rats treated with 2,3,7,8-tetrachlorodibenzo- p -dioxin , Toxicology and Industrial Health, 10.1177/0748233713475497, 31:6, (510-522), Online publication date: 1-Jun-2015. Stohs S and Hassoun E (2011) Dioxin-Activated AHR: Toxic Responses and the Induction of Oxidative Stress The AH Receptor in Biology and Toxicology, 10.1002/9781118140574.ch15, (229-244) Thurmond T, Silverstone A, Baggs R, Quimby F, Staples J and Gasiewicz T (1999) A Chimeric Aryl Hydrocarbon Receptor Knockout Mouse Model Indicates That Aryl Hydrocarbon Receptor Activation in Hematopoietic Cells Contributes to the Hepatic Lesions Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin, Toxicology and Applied Pharmacology, 10.1006/taap.1999.8681, 158:1, (33-40), Online publication date: 1-Jul-1999. Pluim H, van der Goot M, Olie K, van der Slikke J and Koppe J (1996) Missing effects of background dioxin exposure on development of breast-fed infants during the first half year of life, Chemosphere, 10.1016/0045-6535(96)00268-8, 33:7, (1307-1315), Online publication date: 1-Oct-1996. Gasiewicz T (1991) Nitro Compounds and Related Phenolic Pesticides Classes of Pesticides, 10.1016/B978-0-12-334163-1.50006-1, (1191-1269), . Tomaszewski K, Montgomery C and Melnick R (1988) Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in F344 rats by di(2-ethylhexyl)phthalate, Chemico-Biological Interactions, 10.1016/0009-2797(88)90107-X, 65:3, (205-222), . Reitze H and Seitz K (1985) Light and electron microscopical changes in the liver of mice following treatment with aminotriazole, Experimental pathology, 10.1016/S0232-1513(85)80053-0, 27:1, (17-31), Online publication date: 1-Jan-1985. Sweatlock J and Gasiewicz T (1985) The effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure on the concentration of B-hydroxybutyrate and acetoacetate in the rat, Chemosphere, 10.1016/0045-6535(85)90228-0, 14:6-7, (975-978), Online publication date: 1-Jan-1985. Weber G, Luzi P, Resi L, Tanganelli P, Lovati M and Poli A (2009) Natural history of TCDD‐induced liver lesions in rats as observed by transmission electron microscopy during a 32‐week period after a single intraperitoneal injection, Journal of Toxicology and Environmental Health, 10.1080/15287398309530447, 12:4-6, (533-540), Online publication date: 1-Oct-1983. (1981) BIBLIOGRAPHY Criteria (Dose/Effect Relationships) for Organochlorine Pesticides, 10.1016/B978-0-08-023441-0.50023-7, (373-381), . Singh A, Valli V, Ritter L and Villeneuve D (1981) Ultrastructural alterations in the liver of rats fed photomirex (8-Monohydromirex), Pathology, 10.3109/00313028109059066, 13:3, (487-496), . McConnell E, Moore J, Gupta B, Rakes A, Luster M, Goldstein J, Haseman J and Parker C (1980) The chronic toxicity of technical and analytical pentachlorophenol in cattle. I. Clinicopathology, Toxicology and Applied Pharmacology, 10.1016/0041-008X(80)90342-7, 52:3, (468-490), Online publication date: 1-Mar-1980. Olson J, Holscher M and Neal R (1980) Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Golden Syrian hamster, Toxicology and Applied Pharmacology, 10.1016/0041-008X(80)90221-5, 55:1, (67-78), Online publication date: 1-Aug-1980. Kohli K, Gupta B, Albro P, Mukhtar H and McKinney J (1979) Biochemical effects of pure isomers of hexachlorobiphenyl: Fatty livers and cell structure, Chemico-Biological Interactions, 10.1016/0009-2797(79)90042-5, 25:2-3, (139-156), Online publication date: 1-May-1979. Kitchin K and Woods J (1979) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) effects on hepatic microsomal cytochrome P-448-mediated enzyme activities, Toxicology and Applied Pharmacology, 10.1016/0041-008X(79)90524-6, 47:3, (537-546), Online publication date: 1-Mar-1979. Marselos M, Törrönen R and Aitio A (2008) Responses of the D-Glucuronic Acid Pathway in Rat Tissues to Treatment with Tetrachlorodibenzodioxin, Xenobiotica, 10.3109/00498257809070023, 8:7, (397-402), Online publication date: 1-Jan-1978. Aitio A and Parkki M (1978) Organ specific induction of drug metabolizing enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat, Toxicology and Applied Pharmacology, 10.1016/0041-008X(78)90289-2, 44:1, (107-114), Online publication date: 1-Apr-1978. Yang K, Croft W and Peterson R (1977) Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on plasma disappearance and biliary excretion of foreign compounds in rats, Toxicology and Applied Pharmacology, 10.1016/0041-008X(77)90075-8, 40:3, (485-496), Online publication date: 1-Jun-1977. Kociba R, Keeler P, Park C and Gehring P (1976) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): Results of a 13-week oral toxicity study in rats, Toxicology and Applied Pharmacology, 10.1016/0041-008X(76)90078-8, 35:3, (553-574), Online publication date: 1-Mar-1976. Kimbrough R, Barnes M and Greig J (2008) The Toxicity of Polychlorinated Polycyclic Compounds and Related Chemicals, CRC Critical Reviews in Toxicology, 10.3109/10408447309025705, 2:4, (445-498), Online publication date: 1-Jan-1973. Vol. 5September 1973Metrics About Article Metrics Publication History Originally published1 September 1973Published in print1 September 1973 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.