A short efficient preparation of (+) and (−)-trans-2-phenylcyclohexanol
1996; Elsevier BV; Volume: 7; Issue: 11 Linguagem: Inglês
10.1016/0957-4166(96)00409-0
ISSN1362-511X
AutoresBryon Carpenter, Ian R. Hunt, Brian A. Keay,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoAbstract Both enantiomers of trans-2-phenylcyclohexanol (1) (Whitesell's auxiliary) have been prepared in a facile three step sequence starting from phenylmagnesium bromide and cyclohexene oxide using Lipase PS30 to facilitate the resolution of the racemic alcohol (10g) by a kinetic acetylation reaction on a preparative scale.
Referência(s)