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Artigo Revisado por pares
BIBTEX RIS

Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation

2008; Elsevier BV; Volume: 18; Issue: 6 Linguagem: Inglês

10.1016/j.bmcl.2008.01.038

ISSN

1464-3405

Autores

James G. Douglass, J. Bryan deCamp, Emilee H. Fulcher, W. Schuyler Jones, Sanjoy K. Mahanty, Anna Morgan, Dima Smirnov, José L. Boyer, Paul S. Watson,

Tópico(s)

Heart Failure Treatment and Management

Resumo

Modified adenosine derivatives may lead to the development of P2Y(12) antagonists that are potent, selective, and bind reversibly to the receptor. Analogues of 2',3'-trans-styryl acetal-N6-ureido-adenosine monophosphate were prepared by modification of the 5'-position. The resulting analogues were tested for P2Y(12) antagonism in a platelet aggregation assay.

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