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Pontine Myelinolysis in a Child with Carbamate Poisoning

2006; Taylor & Francis; Volume: 44; Issue: 3 Linguagem: Inglês

10.1080/15563650600584543

1556-9519

Raffaéle Santinelli, Carlo Tolone, A D'Avanzo, Emanuele Miraglia del Giudice, Laura Perrone, Michele D’Avanzo,

Muscle and Compartmental Disorders

Carbamate and organophosphate pesticides are widely used all over the world. Poisoning with these substances may produce both immediate and delayed neurotoxic effects. We report the case of a 4-year-old boy who was admitted to the Pediatric Department of the Second University of Naples for evaluation of stupor, lethargy, severe hypotonia, generalized weakness of his arms and legs, ataxia, dysmetria, miosis, excessive salivation and tearing. The pesticide carbaryl (1-naphthyl-N-methylcarbamate) was identified in blood and urine samples. On admission, magnetic resonance imaging (MRI) was unremarkable; on day 11, MRI showed central pontine myelinolysis. The demyelination improved after 4 months and disappeared after 2 years. Various underlying and concomitant diseases have been described in children with central pontine myelinolysis but, to our knowledge, the finding of pontine myelinolysis after carbamate poisoning has not yet been described.