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Contributions of the epidermal growth factor receptor to keratinocyte motility

1998; Wiley; Volume: 43; Issue: 5 Linguagem: Inglês

10.1002/(sici)1097-0029(19981201)43

1097-0029

Laurie G. Hudson, Lisa J. McCawley,

Cell Adhesion Molecules Research

Microscopy Research and TechniqueVolume 43, Issue 5 p. 444-455 Topical PaperFree Access Contributions of the epidermal growth factor receptor to keratinocyte motility Laurie G. Hudson, Corresponding Author Laurie G. Hudson [email protected] Program in Pharmacology and Toxicology, College of Pharmacy and Department of Cell Biology, School of Medicine, University of New Mexico, Albuquerque, New Mexico 87131University of New Mexico Health Sciences Center, Program in Pharmacology and Toxicology, College of Pharmacy, Rm B-80, NRPH, 2502 Marble NE, Albuquerque, NM 87131.Search for more papers by this authorLisa J. McCawley, Lisa J. McCawley Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611Search for more papers by this author Laurie G. Hudson, Corresponding Author Laurie G. Hudson [email protected] Program in Pharmacology and Toxicology, College of Pharmacy and Department of Cell Biology, School of Medicine, University of New Mexico, Albuquerque, New Mexico 87131University of New Mexico Health Sciences Center, Program in Pharmacology and Toxicology, College of Pharmacy, Rm B-80, NRPH, 2502 Marble NE, Albuquerque, NM 87131.Search for more papers by this authorLisa J. McCawley, Lisa J. McCawley Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611Search for more papers by this author First published: 11 December 1998 https://doi.org/10.1002/(SICI)1097-0029(19981201)43:5 3.0.CO;2-CCitations: 71AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The epidermal growth factor (EGF) receptor plays a central role in numerous aspects of keratinocyte biology. In normal epidermis, the EGF receptor is important for autocrine growth of this renewing tissue, suppression of terminal differentiation, promotion of cell survival, and regulation of cell migration during epidermal morphogenesis and wound healing. In wounded skin, the EGF receptor is transiently up-regulated and is an important contributor to the proliferative and migratory aspects of wound reepithelialization. In keratinocytic carcinomas, aberrant expression or activation of the EGF receptor is common and has been proposed to play a role in tumor progression. Many cellular processes such as altered cell adhesion, expression of matrix degrading proteinases, and cell migration are common to keratinocytes during wound healing and in metastatic tumors. The EGF receptor is able to regulate each of these cellular functions and we propose that transient and dynamic elevation of EGF receptor during wound healing, or constitutive overexpression in tumors, provides an important contribution to the migratory and invasive potential of keratinocytes. Microsc. Res. Tech. 43:444–455, 1998. © 1998 Wiley-Liss, Inc. References Aaronson, S. A., Rubin, J. S. Finch, P. W., Wong, J., Marchese, C., Falco, J., Taylor, W. G., and Kraus, M. H. (1990) Growth factor-regulated pathways in epithelial cell proliferation. Am. Rev. Respir. Dis., 142: S7–10. 10.1164/ajrccm/142.6_Pt_2.S7 CASPubMedWeb of Science®Google Scholar Alimandi, M., Wang, L. M., Bottaro, D., Lee, C. C., Kuo, A., Frankel, M., Fedi, P., Tang, C., Lippman, M., and Pierce, J. H. (1997) Epidermal growth factor and betacellulin mediate signal transduction through co-expressed erbB2 and erbB3 receptors. 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