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Pathophysiology of focal segmental glomerulosclerosis

2007; Springer Science+Business Media; Volume: 22; Issue: 3 Linguagem: Inglês

10.1007/s00467-006-0357-2

1432-198X

Kimberly Reidy, Frederick J. Kaskel,

Autoimmune Bullous Skin Diseases

Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal models and studies of familial forms of nephrotic syndrome helped elucidate some mechanisms of podocyte injury and disease progression in FSGS. This article reviews some of the experimental and clinical data on the pathophysiology of FSGS.