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The Preparation and the Antibacterial and Antifungal Properties of Some Substituted Benzyl Alcohols

1958; Oxford University Press; Volume: 10; Issue: Supplement_1 Linguagem: Inglês

10.1111/j.2042-7158.1958.tb10394.x

2042-7158

D V Carter, P. T. Charlton, A H Fenton, J. R. Housley, B. Lessel,

Synthesis of Organic Compounds

Abstract A number of substituted benzyl alcohols have been prepared and together with some related, commercially available, compounds have been tested for antibacterial and antifungal properties. The most active inhibitory compound was 3:4:5-trichlorobenzyl alcohol followed by 4-chloro-3:5-dimethyl-, 3:4-dichloro- and 2:4-dichlorobenzyl alcohols, but saturated aqueus solutions of the last three compounds were more rapidly bactericidal. Pharmacological tests have shown that 2:4-dichlorobenzyl alcohol has low toxicity.