Produção Nacional
Revisado por pares
Determinação espectroscópica multivariada de glucosamina e condroitina em formulações farmacêuticas
2008; Brazilian Chemical Society; Volume: 31; Issue: 6 Linguagem: Inglês
10.1590/s0100-40422008000600002
ISSN1678-7064
AutoresPaula Rossignoli, Roberto Pontarolo, Cassyano Januário Correr, Gilcélia A. Cordeiro, Patrício Peralta-Zamora,
Tópico(s)Proteoglycans and glycosaminoglycans research
ResumoFORMULATIONS.The objective of this study was to develop and validate an analytical method for quantification of glucosamine and chondroitin in pharmaceutical formulations.Multivariate calibration combined with infrared spectrophotometry allowed this analysis.25 mixtures of glucosamine-6-sulphate and chondroitin-6-sulphate were used for calibration.Average errors found with this model during external validation were 1.37% for glucosamine sulphate and 1.30% for chondroitin sulphate.This method presented satisfactory results for assessed variables, what indicating that it is suitable for simultaneous quantification of glucosamine and chondroitin.
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