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8-Methyl-Pyridoxatin: A Novel N -Hydroxy Pyridone from Fungus OS-F61800 That Induces Erythropoietin in Human Cells

1999; American Chemical Society; Volume: 62; Issue: 2 Linguagem: Inglês

10.1021/np980450t

1520-6025

Ping Cai, David F. Smith, Bernadette Cunningham, Sheryl Brown‐Shimer, Barry Katz, Cedric J. Pearce, Debra A. Venables, David R. Houck,

Fungal Biology and Applications

In the course of screening for small-molecule modulators of erythropoietin gene expression, a novel N-hydroxy pyridone was isolated from a culture of OS-F61800. Its structure was elucidated by extensive 1H and 13C NMR spectroscopic and chemical studies. This compound induced erythropoietin gene expression fivefold at a concentration of 0.3 microM, which is about threefold greater potency than our previously identified erythropoietin inducers.