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Human CD4+ memory T-lymphocyte responses to SARS coronavirus infection

2007; Elsevier BV; Volume: 368; Issue: 2 Linguagem: Inglês

10.1016/j.virol.2007.07.015

1096-0341

Daniel H. Libraty, Kimberly M. O'Neil, Lauren M. Baker, Luz P. Acosta, Remigio M. Olveda,

vaccines and immunoinformatics approaches

Little is known about CD4+ T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4+ T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4+ T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4+ T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4+ memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4+ T-cell immune responses.