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Sexual Transmission of an HIV-1 Variant Resistant to Multiple Reverse-Transcriptase and Protease Inhibitors

1998; Massachusetts Medical Society; Volume: 339; Issue: 5 Linguagem: Inglês

10.1056/nejm199807303390504

1533-4406

Frederick Hecht, Robert M. Grant, Christos J. Petropoulos, Beth Dillon, Margaret A. Chesney, Huan Tian, Nicholas S. Hellmann, Nirmala I. Bandrapalli, Laura Digilio, Bernard M. Branson, James O. Kahn,

HIV/AIDS Research and Interventions

Combination treatments with agents that inhibit protease and reverse transcriptase of human immunodeficiency virus type 1 (HIV-1) decrease mortality and slow disease progression.1 The development of resistance to these drugs, however, limits the benefit of such treatments.2,3 There have been reports of the transmission of HIV-1 variants that are resistant to nucleoside and non-nucleoside inhibitors of reverse transcriptase.4–9 The transmission of HIV-1 variants that are resistant to protease inhibitors could represent an important emerging clinical and public health problem. We report a case of transmission of an HIV-1 variant with multiple mutations that conferred resistance to both protease . . .