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Association Among SNAP-25 Gene Dde I and Mnl I Polymorphisms and Hemodynamic Changes During Methylphenidate Use

2010; SAGE Publishing; Volume: 15; Issue: 8 Linguagem: Inglês

10.1177/1087054710374597

1557-1246

Özgür Öner, Ata Akın, Hasan Herken, Mehmet Emin Erdal, Koray Çiftçi, Mustafa Ertan Ay, Duygu Şahin Biçer, Bedriye Öncü, Özlem Hekim Bozkurt, Kerim Münir, Yankı Yazgan,

Neural and Behavioral Psychology Studies

To investigate the interaction of treatment-related hemodynamic changes with genotype status for Synaptosomal associated protein 25 (SNAP-25) gene in participants with attention deficit hyperactivity disorder (ADHD) on and off single dose short-acting methylphenidate treatment with functional near-infrared spectroscopy (fNIRS).A total of 15 right-handed adults and 16 right-handed children with DSM-IV diagnosis of ADHD were evaluated. Ten milligrams of short-acting methylphenidate was administered in a crossover design.Participants with SNAP-25 DdeI T/T genotype had decreased right deoxyhemoglobin ([HHb]) with treatment. SNAP-25 MnlI genotype was also associated with right deoxyhemoglobin ([HbO2]) and [HHb] changes as well as left [HHb] change. When the combinations of these genotypes were taken into account, the participants with [DdeI C/C or T/C and MnlI G/G or T/G] genotype had increased right [HHb] with MPH use whereas the participants with [DdeI T/T and MnlI T/T] or [DdeI T/T and MnlI G/G or T/G] genotypes had decreased right prefrontal [HHb].These results suggested that SNAP-25 polymorphism might be associated with methylphenidate induced brain hemodynamic changes in ADHD participants.