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The Effects of Acute and Repeated Restraint Stress on the Nociceptive Response in Rats

1998; Elsevier BV; Volume: 63; Issue: 4 Linguagem: Inglês

10.1016/s0031-9384(97)00520-9

1873-507X

Giovana Duzzo Gamaro, Marcia Henriques Xavier, J.D. Denardin, Jennifer Pilger, Daniela Roesch Ely, Maria Beatriz Cardoso Ferreira, Carla Dalmaz,

Neurotransmitter Receptor Influence on Behavior

Gamaro, G. D., M. H. Xavier, J. D. Denardin, J. A. Pilger, D. R. Ely, M. B. C. Ferreira, C. Dalmaz. The effects of acute and repeated restraint stress on the nociceptive response in rats. Physiol Behav 63(4) 693–697, 1998. The effects of acute and repeated restraint stress on nociception, as measured by the tail-flick latency, were studied in adult male and female rats. After the exposure to a single restraint session, both male and female rats presented an increased latency in the tail-flick test. On the other hand, chronically stressed females presented a performance similar to the control group, whereas chronically stressed male rats responded to restraint with a decrease in the tail-flick latency. This response could be determined by the chronic treatment itself or by the restraint done just before the measurement. Thus, the effect of chronic stress upon basal tail-flick latency was evaluated. In male rats, this latency was significantly decreased in the stressed animals compared with the control group. In female rats, no difference between those groups was observed. Therefore, the results suggest that: (a) acute restraint stress induces an analgesic response in both male and female rats, and (b) there is a gender-specific nociceptive response induced by repeated restraint stress with a hyperalgesic effect in response to stress only in males.