Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Synergy effects of the antibiotics gentamicin and the essential oil of Croton zehntneri

2009; Elsevier BV; Volume: 16; Issue: 11 Linguagem: Inglês

10.1016/j.phymed.2009.04.004

1618-095X

Fabíola Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho,

Bioactive Natural Diterpenoids Research

The leaves of Croton zehntneri Pax et Hoffm (Euphorbiaceae) were subjected to hydrodistillation, and the essential oil extracted was examined with respect to antibacterial and antibiotic modifying activity by gaseous contact. The gaseous component of the oil inhibited the bacterial growth of Staphylococcus aureus and Pseudomonas aeruginosa with a MID of 0.5 and<1mg/l air, respectively. The activity of the antibiotic gentamicin was increased by 42,8% against P. aeruginosa after contact with the gaseous component, showing that this oil influences the activity of the antibiotic and may be used as an adjuvant in the antibiotic therapy of respiratory tract bacterial pathogens.