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The synthesis of certain 11,14-dimethoxydeoxypodocarpic acid derivatives. an application to the synthesis of (+)-winterin from drimys winteri

1977; Elsevier BV; Volume: 33; Issue: 9 Linguagem: Inglês

10.1016/0040-4020(77)80220-2

1464-5416

S. William Pelletier, Yasou Ohtsuka,

Biological Activity of Diterpenoids and Biflavonoids

This paper reports the synthesis of several 11,14-dimethoxydeoxypodocarpic acid derivatives from (+)-podocarpic acid. The synthesis of the naturally occurring sesquiterpene, (+)-winterin, from Drimys winteri illustrates a synthetic application of the 11,14-dimethoxy intermediates and establishes the absolute configuration for winterin.