Specificity of leukocyte-endothelial interactions and diapedesis: physiologic and therapeutic implications of an active decision process
1993; Elsevier BV; Volume: 144; Issue: 9 Linguagem: Inglês
10.1016/s0923-2494(93)80053-2
ISSN1879-1425
Autores Tópico(s)Immune Response and Inflammation
ResumoIn situ studies have revealed that an active multistep process regulates leukocyte-endothelial cell recognition and diapedesis in vivo. The requirement for sequential engagement of receptors mediating transient adhesion, leukocyte activation, activationdependent sticking and diapedesis implies that leukocyte recruitment can be regulated at any of these 4 steps, and provides a combinatorial mechanism to explain the remarkable specificity and diversity of leukocyte homing events in vivo. The model will help direct therapeutic approaches to controlling leukocyte traffic.
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