Revisão Acesso aberto Revisado por pares

The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics.

1979; Wiley; Volume: 7; Issue: 5 Linguagem: Inglês

10.1111/j.1365-2125.1979.tb00986.x

ISSN

1365-2125

Autores

LF Prescott,

Tópico(s)

Drug Transport and Resistance Mechanisms

Resumo

British Journal of Clinical PharmacologyVolume 7, Issue 5 p. 453-462 Free Access The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics. LF Prescott, LF PrescottSearch for more papers by this author LF Prescott, LF PrescottSearch for more papers by this author First published: May 1979 https://doi.org/10.1111/j.1365-2125.1979.tb00986.xCitations: 31AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References Adriaenssens, P.I. & Prescott, L.F. (1978). 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Molecular basis for several drug-induced nephropathies. Am. J. Med., 62, 518– 526. Mitchell, J.R., Potter, W.Z., Hinson, J.A., Snodgrass, W.R., Timbrell, J.A. & Gillette, J.R. (1975). Toxic drug reactions. In Concepts in Biochemical Pharmacology., J.R. Eds. Gillette & J.R. Mitchell, pp. 383– 419. New York: Springer-Verlag. Mitchell, J.R., Thorgeirsson, S.S., Potter, W.Z., Jollow, D.J. & Keiser, H. (1974). Acetaminophen-induced hepatic injury: Protective role of glutathione in man and rationale for therapy. Clin. Pharmac. Ther., 16, 676– 684. Molland, E.A. (1978). Experimental renal papillary necrosis. Kidney International, 13, 5– 14. Nanra, R.S., Chirawong, P. & Kincaid-Smith, P. (1973). Medullary ischaemia in experimental analgesic nephropathy-The pathogenesis of renal papillary necrosis. Aust. N.Z. J. Med., 3, 580– 586. Nanra, R.S., Stuart-Taylor, J., De Leon, A.H. & White, K.H. (1978). Analgesic nephropathy: Etiology, clinical syndrome, and clinicopathologic correlations in Australia. Kidney International, 13, 79– 92. Nimmo, J., Dixon, M.F. & Prescott, L.F. (1973). Effects of mepyramine, promethazine and hydro-cortisone on paracetamol-induced hepatic necrosis in the rat. Clin. Toxicol. 6, 75– 81. Piperno, E. & Berssenbruegge, D.A. (1976). Reversal of experimental paracetamol toxicosis with N-acetylcysteine. Lancet, ii, 738– 739. Potter, W.Z., Davis, D.C., Mitchell, J.R., Jollow, D.J., Gillette, J.R. & Brodie, B.B. (1973). Acetaminophen-induced hepatic necrosis. III. Cytochrome P-450—mediated covalent binding in vitro. J. Pharmac. exp. Ther., 187, 203– 210. Prescott, L.F. (1965). Effects of acetylsalicylic acid, phenacetin, paracetamol, and caffeine on renal tubular epithelium. Lancet, ii, 91– 96. Prescott, L.F. (1966a). The nephrotoxicity of analgesics. J. Pharm. Pharmac., 18, 331– 344. Prescott, L.F. (1966b). Analgesic abuse and renal disease in North-East Scotland. Lancet, ii, 1143– 1145. Prescott, L.F. (1969). The metabolism of phenacetin in patients with renal disease. Clin. Pharmac. Ther., 10, 383– 394. Prescott, L.F. (1971). Gas-liquid chromatographic estimation of paracetamol. J. Pharm. Pharmac., 23, 807– 808. Prescott, L.F. (1975). Antipyretic analgesics. In Meyler's Side Effects of Drugs, 8, 154– 206. Ed. M.N.G. Dukes Amsterdam: Excerpta Medica. Prescott, L.F. (1977). Antipyretic analgesics. In Side Effects of Drugs Annual I., Ed. M.N.G. Dukes, pp. 64– 85. Amsterdam: Excerpta Medica. Prescott, L.F. (1978a). Antipyretic analgesics. In Side Effects of Drugs Annual II., Ed. M.N.G. Dukes, pp. 79– 90. Amsterdam: Excerpta Medica. Prescott, L.F. (1978b). Prevention of hepatic necrosis following paracetamol overdosage. Health Bulletin, 36, 204– 212. Prescott, L.F. (1979a). Antipyretic analgesics. In Side Effects of Drugs Annual III., Ed. M.N.G. Dukes, Amsterdam: Excerpta Medica. (in press). Prescott, L.F. (1979b). Drug-induced renal disease — a clinical pharmacologists view. Eur. J. Rheum. Inflamm. (in press). Prescott, L.F. & Ansari, S. (1969). The effects of repeated administration of mercuric chloride on exfoliation of renal tubular cells and urinary glutamic-oxaloacetic transaminase activity in the rat. Tox. appl. Pharmac., 14, 97– 107. Prescott, L.F. & Brodie, D.E. (1964). A simple differential stain for urinary sediment. Lancet, ii, 940. Prescott, L.F., Newton, R.W., Swainson, C.P., Wright, N., Forrest, A.R.W. & Matthew, H. (1974). Successful treatment of severe paracetamol overdosage with cysteamine. Lancet, i, 588– 592. Prescott, L.F., Oswald, I. & Proudfoot, A.T. (1978). Repeated self-poisoning with paracetamol. Br. med J., 2, 1399. Prescott, L.F., Park, J., Ballantyne, A., Adriaenssens, P. & Proudfoot, A.T. (1977). Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet, ii, 432– 434. Prescott, L.F. Park, J., Sutherland, G.R., Smith, I.J. & Proudfoot, A.T. (1976). Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. Lancet, ii, 109– 113. Prescott, L.F., Sansur, M., Levin, W. & Conney, A.H. (1968). The comparative metabolism of phenacetin and N-acetyl-p-aminophenol in man, with particular reference to effects on the kidney. Clin. Pharmac. Ther., 9, 605– 614. Prescott, L.F., Steel, R.F. & Ferrier, W.R. (1970). The effects of particle size on the absorption of phenacetin in man. Clin. Pharmac. Ther., 11, 496– 504. Prescott, L.F. & Wright, N. (1973). The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. Br. J. Pharmac., 49, 602– 613. Prescott, L.F., Wright, N., Roscoe, P. & Brown, S.S. (1971). Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet, i, 519– 522. Raaflaub, J. & Dubach, U.C. (1969). Dose-dependent change in the pattern of phenacetin metabolism in man and its possible significance in analgesic nephropathy. Klin. Wschr., 47, 1286– 1287. Scott, J.T., Denman, A.M. & Dorling, J. (1963). Renal irritation caused by salicylates. Lancet, i, 344– 348. Shelley, J.H. (1978). Pharmacological mechanisms of analgesic nephropathy. Kidney International, 13, 15– 26. Smith, J.M., Roberts, W.O., Hall, S.M., White, T.A. & Gilbertson, A.A. (1978). Late treatment of paracetamol poisoning with mercaptamine. Br. med. J., 1, 331– 333. Spühler, O. & Zollinger, H.U. (1953). Die Chronische interstitielle Nephritis. Z. Klin. Med., 151, 1– 50. Stewart, M.J., Adriaenssens, P.I., Jarvie, D.R. & Prescott, L.F. (1979). Inappropriate methods for the emergency estimation of plasma paracetamol. Ann. Clin. Biochem. (in press). Thomson, J.S. & Prescott, L.F. (1966). Liver damage and impaired glucose tolerance after paracetamol overdosage. Br. med. J., 2, 506– 507. Wiseman, E.H. & Reinert, H. (1975). Anti-inflammatory drugs and renal papillary necrosis. Agents Actions, 5, 322– 325. Wright, N. & Prescott, L.F. (1973). Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage. Scot. med. J., 18, 56– 58. Citing Literature Volume7, Issue5May 1979Pages 453-462 ReferencesRelatedInformation

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