GOLD and ABCD—a good start, but now for the evidence?
2012; Elsevier BV; Volume: 1; Issue: 1 Linguagem: Inglês
10.1016/s2213-2600(12)70045-0
ISSN2213-2619
Autores Tópico(s)Asthma and respiratory diseases
ResumoChronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality, and increasing evidence shows that there is considerable heterogeneity in COPD populations. Patients experience exacerbations which are episodes of worsening symptoms and these can have significant effects on the disease course. 1 Wedzicha JA Seemungal TAR COPD exacerbations: defining their cause and prevention. Lancet. 2007; 370: 786-796 Summary Full Text Full Text PDF PubMed Scopus (806) Google Scholar Some patients are particularly susceptible to these exacerbations and are at risk of worse outcomes. Those with two or more treated exacerbations per year are referred to as frequent exacerbators. 2 Hurst JR Vestbo J Anzueto A et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010; 63: 1128-1138 Crossref Scopus (2204) Google Scholar GOLD 2011 disease severity classification in COPDGene: a prospective cohort studyThe GOLD classification emphasises the importance of symptoms and exacerbation risk when assessing COPD severity. The choice of symptom measure influences category assignment. The relative number of patients with low symptoms and high risk for exacerbations (category C) is low. Differences in exacerbation rates for patients in the highest risk category D were seen depending on whether risk was based on lung function, exacerbation history, or both. Full-Text PDF
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