Germinal-centre reactions in allergic inflammation
2006; Elsevier BV; Volume: 27; Issue: 10 Linguagem: Inglês
10.1016/j.it.2006.08.007
ISSN1471-4981
AutoresHannah J. Gould, Pooja Takhar, Helen E. Harries, Stephen R. Durham, Christopher J. Corrigan,
Tópico(s)Asthma and respiratory diseases
ResumoPrimary and secondary immune responses in the germinal centres of lymphoid organs have been studied in the past. There is now compelling evidence of a third stage in the immune response, in 'tertiary lymphoid organs' that develop at sites of chronic inflammation in response to persistent local antigen challenge. Germinal-centre-like reactions are well-documented in the target organs of autoimmune diseases. Here, we review recent evidence that they also occur at sites of allergic inflammation. Primary and secondary immune responses in the germinal centres of lymphoid organs have been studied in the past. There is now compelling evidence of a third stage in the immune response, in 'tertiary lymphoid organs' that develop at sites of chronic inflammation in response to persistent local antigen challenge. Germinal-centre-like reactions are well-documented in the target organs of autoimmune diseases. Here, we review recent evidence that they also occur at sites of allergic inflammation.
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