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Oxcarbazepine concentrations during pregnancy: A retrospective study in patients with epilepsy

2006; Lippincott Williams & Wilkins; Volume: 67; Issue: 8 Linguagem: Inglês

10.1212/01.wnl.0000240047.11166.0e

1526-632X

Jakob Christensen, Anne Sabers, Per Sidenius,

Pregnancy and Medication Impact

We assessed the concentration of the oxcarbazepine metabolite 10-hydroxycarbazepine (MHD) in nine pregnancies among seven women before, during, and after pregnancy. The mean dose-corrected concentration of MHD was decreased during pregnancy (analysis of variance, p = 0.0016), being 72% (SD = 13%) in the first trimester, 74% (SD = 17%) in the second trimester, 64% (SD = 6%) in the third trimester, and 108% (SD = 18%) after pregnancy vs the dose-corrected concentration before pregnancy.