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METABOLISM OF [4-14C]PROGESTERONE IN THE RHESUS MONKEY (MACACA MULATTA)

1969; Bioscientifica; Volume: 43; Issue: 3 Linguagem: Inglês

10.1677/joe.0.0430493

1479-6805

T. M. Plant, V.H.T. James, R. P. MICHAEL,

Adrenal Hormones and Disorders

Few data are available on the metabolism of progesterone in infra-human primates. Using gas chromatography, Chamberlain, Knights & Thomas (1964) detected 5β-pregnane-3α,20α-diol in the urine of pregnant rhesus monkeys and in the urine of a male injected with a large dose of progesterone, although quantitative data were lacking. While it would appear that the metabolism of progesterone in an anthropoid ape, such as the chimpanzee, is similar to that in man (Romanoff, Grace, Sugarman & Pincus, 1963), the observations of Jeffery (1966) have indicated that this may not be the case in a catarrhine monkey. We have therefore studied the excretion of progesterone metabolites in the urine and faeces of the rhesus macaque (Macaca mulatta). Five adult, female rhesus monkeys (4·6–7·1 kg. body weight) each received approximately 25 [4-14C]progesterone i.v. (Table 1), and were then placed either in primate restraining chairs or metabolism cages in order to make