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Relationship of Amyloid-Beta Burden With Age-At-Onset in Alzheimer Disease

2010; Elsevier BV; Volume: 19; Issue: 7 Linguagem: Inglês

10.1097/jgp.0b013e318202bf3a

1545-7214

Il Han Choo, Dong Young Lee, Jee Wook Kim, Eun Hyun Seo, Dong Soo Lee, Yu Kyeong Kim, Shin Gyeom Kim, Chul‐Kee Park, Jong Inn Woo, Eun Jin Yoon,

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Objective: To investigate the relationship between in vivo brain amyloid-beta (Aβ) burden, measured by 11 C-labeled Pittsburgh Compound B ( 11 C-PiB) retention, and age-at-onset in patients with Alzheimer disease (AD). Design: Cross-sectional study. Setting: University Dementia Clinic. Participants: Twenty-two AD patients including 11 early-onset AD (EOAD: onset <65 years) and 11 late-onset AD (LOAD: onset ≥65years) cases with matched dementia severity, duration of illness, and apolipoprotein E ɛ4 allele number. Intervention: 11 C-PiB positron emission tomography scans. Measurements: Both region of interest and voxel-based analyses were performed to compare 11 C-PiB retention between EOAD and LOAD groups, and to test linear relationship between age-at-onset and 11 C-PiB retention. Results: Both region of interest (ROI) and voxel-based analyses revealed that EOAD patients had significantly higher 11 C-PIB retentions than LOAD patients in diffuse brain regions including frontal, lateral parietal, lateral temporal, and occipital cortex, and basal ganglia. Subgroup analyses showed that negative correlation between age-at-onset and 11 C-PiB retention was significant in LOAD but not in EOAD. Conclusions: Our finding of a heavier Aβ burden in the brain of living EOAD patients than LOAD patients is in agreement with those from postmortem studies. The inverse relationship between age-at-onset and Aβ burden is possibly associated with aging-related decrease of brain or cognitive reserve and with aging-related increase of brain vulnerability.