Cellular Factors Required for Lassa Virus Budding
2006; American Society for Microbiology; Volume: 80; Issue: 8 Linguagem: Inglês
10.1128/jvi.80.8.4191-4195.2006
ISSN1098-5514
AutoresShuzo Urata, Takeshi Noda, Yoshihiro Kawaoka, Hideyoshi Yokosawa, Jiro Yasuda,
Tópico(s)Viral Infections and Vectors
ResumoABSTRACT It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding. We demonstrated that Lassa Z protein efficiently produces VLPs and uses cellular factors, Vps4A, Vps4B, and Tsg101, in budding, suggesting that Lassa virus budding uses the multivesicular body pathway functionally. Our data may provide a clue to develop an effective antiviral strategy for Lassa virus.
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