Levels of topoisomerase II and DNA polymerase α are regulated independently in developing neuronal nuclei
1986; Elsevier BV; Volume: 138; Issue: 3 Linguagem: Inglês
10.1016/s0006-291x(86)80398-9
ISSN1090-2104
AutoresKimiko Tsutsui, Ken‐Ichiro Tsutsui, Hiroko Sakurai, Toshikiyo Shohmori, Takuzo Oda,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoA possible correlation between activity levels of topoisomerase II and DNA polymerase α was studied in neuronal nuclei from developing rat brain. A high level of canonical topoisomerase II activity was detected in neuronal nuclei throughout the development even at a late stage (28 days after birth) when the activity of DNA polymerase α decreased to less than 2 % of the fetal level. Thus, in contrast to other systems, topoisomerase II does not change in parallel with DNA polymerase α during neuronal development. Our results suggest that topoisomerase II is required to maintain some fundamental processes in differentiated cells, including transcription.
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