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Synthesis, structure, and antitumor activity of 1,3-dithiol- and 1,3-dithiolan-2-ylidenemalonatoplatinum(II) complexes

1994; Elsevier BV; Volume: 54; Issue: 2 Linguagem: Inglês

10.1016/0162-0134(94)80024-3

1873-3344

Youn Soo Sohn, Kwan Mook Kim, Jong Hwa Jeong, Dong Youn Noh, Chong Ock Lee, Sang Un Choi,

Click Chemistry and Applications

1,3-Dithiol- and 1,3-dithiolan-2-ylidenemalonatoplatinum(II) complexes A2Pt(OOC)2  CR2 (A = NH3, cyclopropylamine (CPA) or A2 = ethylenediamine(EDA), trans(±)-1,2-diaminocyclohexane(DACH); R2 = -SCH  CHS-, -SCH2CH2S-) have been synthesized and subjected to in vivo assay for antitumor activity after characterization by means of elemental analysis, IR spectroscopy, and x-ray analysis. The molecular structure of (CPA)2Pt(OOC)2C  CSCH  CHS has been determined by x-ray diffraction: space group P21/n, a = 7.955(1), b= 16.912(2), c = 15.116(2) Å, β = 102.74(1)°, z = 4, R = 0.032, Rw = 0.035. Among the Pt(II) complexes studied, biscyclopropylamineplatinum(II) complexes both of the above-mentioned dicarboxylate leaving groups exhibited much higher antitumor activity against the leukemia L1210 cell line compared with the known cisplatin.