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Induction of differentiation in mouse neuroblastoma cells by hexamethylene bisacetamide

1977; Elsevier BV; Volume: 76; Issue: 3 Linguagem: Inglês

10.1016/0006-291x(77)91592-3

1090-2104

Clive Palfrey, Yosef Kimhi, Uriel Z. Littauer, Roberta C. Reuben, Paul A. Marks,

Ion channel regulation and function

Hexamethylene bisacetamide (HMBA), a potent inducer of erythroid differentiation in murine erythroleukemia cells (1), induces differentiation in mouse neuroblastoma cells, as indicated by the extension of neurites and the development of an excitable membrane. HMBA is effective at concentrations 50-fold lower than dimethylsulfoxide (2), another inducer of differentiation in both mouse neuroblastoma and murine erythroleukemia cells.