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Biologically Active Oligodeoxyribonucleotides - IV: Anti-HIV-1 Activity of Tgggag Having Hydrophobic Substituent at Its 5′-End via Phosphodiester Linkage

1996; Taylor & Francis; Volume: 15; Issue: 1-3 Linguagem: Inglês

10.1080/07328319608002403

2332-3892

Hitoshi Hotoda, Makoto Koizumi, Rika Koga, Kenji Momota, Toshinori Ohmine, Hidehiko Furukawa, Takashi Nishigaki, Takeshi Kinoshita, Masakatsu Kaneko, Satoshi Kimura, Kaoru Shimada,

DNA and Nucleic Acid Chemistry

Abstract Hexadeoxyribonucleotides (6-mers) having a 5′-TGGGAG-3′ sequence bearing hydrophobic substituents at their 5′-ends via phosphodiester linkages were prepared and evaluated for anti-HIV-1 activity in vitro. Some of these modified 6-mers showed weak anti-HIV-1 activities and they were less potent than the 6-mer having a DMTr group directly attached at its 5′-terminus. 1. Part 111: Hotoda, H.; Koizumi, M.; Koga, R.; Momota, K.; Ohmine, T.; Furukawa, H.; Nishigaki, T.; Kinoshita, T.; Kaneko, M.; Kimura, S.; and Shimada, K. (1994) Proceedings of First International Antisense Conjierence of Japan p62 (Pl-24): In print in Antisense Research and Development. §This paper is dedicated to Dr. Yoshihisa Mizuno, Emeritus Professor of Hokkaido University, on the occasion of his 75th birthday. Notes 1. Part 111: Hotoda, H.; Koizumi, M.; Koga, R.; Momota, K.; Ohmine, T.; Furukawa, H.; Nishigaki, T.; Kinoshita, T.; Kaneko, M.; Kimura, S.; and Shimada, K. (1994) Proceedings of First International Antisense Conjierence of Japan p62 (Pl-24): In print in Antisense Research and Development. §This paper is dedicated to Dr. Yoshihisa Mizuno, Emeritus Professor of Hokkaido University, on the occasion of his 75th birthday.