Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature
2001; Elsevier BV; Volume: 63; Issue: 3 Linguagem: Inglês
10.1016/s0010-7824(01)00184-6
ISSN1879-0518
AutoresHoracio B. Croxatto, Luigi Devoto, Marta Durand, Enrique Ezcurra, Fernando Larrea, Carlos A. Nagle, María Elena Ortiz, David Vantman, Margarita Vega, Helena von Hertzen,
Tópico(s)Ectopic Pregnancy Diagnosis and Management
ResumoThis paper focuses on the research efforts undertaken to understand how emergency contraception (EC) methods act to prevent pregnancy and to identify what is known and what are the important gaps that need to be addressed. Divided into five sections the first section presents a discussion on the background of the review and a brief description of the mode of use efficacy and most common side effects of the Yuzpe regimen levonorgestrel (LNG) and mifepristone. Section 2 includes studies on the effects of postcoital steroid administration upon fertility in nonprimate animal models. Section 3 focuses on the effects of estrogens progestins or the antiprogestin mifepristone administered in the preovulatory period to macaques and the New World monkey Cebus apella. Section 4 highlights clinical studies on the effects of the Yuzpe regimen administered before and after the luteinizing hormone surge and on progesterone-regulated endometrial proteins. Finally section 5 identifies some of the most difficult areas of the literature that need to be researched.
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