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Drosophila blastoderm patterning

2012; Elsevier BV; Volume: 22; Issue: 6 Linguagem: Inglês

10.1016/j.gde.2012.10.005

1879-0380

Johannes Jaeger, Manu Manu, John Reinitz,

Genomics and Chromatin Dynamics

The Drosophila blastoderm embryo is a classic model for the study of the genetics of pattern formation. In recent years, quantitative empirical approaches have been employed extensively in the study of blastoderm pattern formation. This quantitative work has enabled the development of a number of data-driven computational models. More than in other systems, these models have been experimentally validated, and have informed new empirical work. They have led to insights into the establishment of morphogen gradients, the interpretation and transduction of positional information by downstream transcriptional networks, and the mechanisms by which spatial scaling and robustness of gene expression are achieved. Here we review the latest developments in the field.