Are PU.1 mutations frequent genetic events in acute myeloid leukemia (AML)?
2002; Elsevier BV; Volume: 100; Issue: 13 Linguagem: Inglês
10.1182/blood-2002-08-2563
ISSN1528-0020
AutoresCharlotte Lamandin, C. Sagot, Christophe Roumier, Pascale Lepelley, Stéphane de Botton, Alain Cosson, Pierre Fenaux, Claude Preudhomme,
Tópico(s)Chemical Synthesis and Analysis
ResumoRecently, Mueller et al[1][1] found PU.1 mutations in 7% of the 126 cases of acute myeloid leukemia (AML) they analyzed. DNA binding and transactivation of the M-CSF receptor promoter, a direct PU.1 target gene, were deficient in the 7 mutants that affected the DNA-binding domain of the PU.1. Those
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