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Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci

2015; Nature Portfolio; Volume: 6; Issue: 1 Linguagem: Inglês

10.1038/ncomms6966

2041-1723

Regina C. Betz, Lynn Petukhova, Stephan Ripke, Hailiang Huang, Androniki Menelaou, Silke Redler, Tim Becker, Stefanie Heilmann‐Heimbach, Tarek Yamany, Madeliene Duvic, Maria Hordinsky, David A. Norris, Vera H. Price, Julian Mackay‐Wiggan, Annemieke de Jong, Gina M. DeStefano, Susanne Moebus, Markus Böhm, Ulrike Blume‐Peytavi, Hans Wolff, Gerhard Lutz, Roland Kruse, Bian Li, Christopher I. Amos, Annette Lee, Peter K. Gregersen, Bettina Blaumeiser, David Altshuler, Raphael Clynes, Paul I. W. de Bakker, Markus M. Nöthen, Mark J. Daly, Angela M. Christiano,

melanin and skin pigmentation

Alopecia areata (AA) is a prevalent autoimmune disease with 10 known susceptibility loci. Here we perform the first meta-analysis of research on AA by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a total of 3,253 cases and 7,543 controls. The strongest region of association is the major histocompatibility complex, where we fine-map four independent effects, all implicating human leukocyte antigen-DR as a key aetiologic driver. Outside the major histocompatibility complex, we identify two novel loci that exceed the threshold of statistical significance, containing ACOXL/BCL2L11(BIM) (2q13); GARP (LRRC32) (11q13.5), as well as a third nominally significant region SH2B3(LNK)/ATXN2 (12q24.12). Candidate susceptibility gene expression analysis in these regions demonstrates expression in relevant immune cells and the hair follicle. We integrate our results with data from seven other autoimmune diseases and provide insight into the alignment of AA within these disorders. Our findings uncover new molecular pathways disrupted in AA, including autophagy/apoptosis, transforming growth factor beta/Tregs and JAK kinase signalling, and support the causal role of aberrant immune processes in AA. Alopecia areata (AA) is a common autoimmune disease with a known genetic component. Here, the authors analyse 3,253 AA patients and 7,543 healthy controls, and identify two new risk loci and disrupted immune response pathways associated with the disease.