HLA B27 polymorphism in Western India
2002; Wiley; Volume: 60; Issue: 1 Linguagem: Inglês
10.1034/j.1399-0039.2002.600115.x
ISSN1399-0039
AutoresU. Shankarkumar, Kanjaksha Ghosh, D. Mohanty,
Tópico(s)Immunodeficiency and Autoimmune Disorders
ResumoAbstract: We have characterized HLA B27 alleles in a sample population of Maharastra, Western Indians ( n = 51), with the aim to investigate the different subtypes present among this population. The study was carried out using polymerase chain reaction with sequence‐specific primers (PCR‐SSP) and reverse line strip (RLS) techniques. Significant new findings have arisen from this study: B*2704, B*2705, B*2707, B*2708 and B*2714 alleles were found to be present, and two novel B27 alleles, B*2708 and B*2714, were found in this Indian population. In addition, B*2714 was observed in a patient with ankylosing spondylitis. This association has not been previously reported in ethnic groups from India.
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