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Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells

2013; American Society for Microbiology; Volume: 87; Issue: 17 Linguagem: Inglês

10.1128/jvi.01562-13

1098-5514

Xinrong Tao, Terence E. Hill, Chikao Morimoto, C. J. Peters, Thomas G. Ksiazek, Chien‐Te K. Tseng,

Viral gastroenteritis research and epidemiology

The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.