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BIBTEX RIS

Formation of dTDP-Rhamnose Is Essential for Growth of Mycobacteria

2002; American Society for Microbiology; Volume: 184; Issue: 12 Linguagem: Inglês

10.1128/jb.184.12.3392-3395.2002

ISSN

1098-5530

Autores

Yufang Ma, Fei Pan, Michael McNeil,

Tópico(s)

Cancer therapeutics and mechanisms

Resumo

ABSTRACT It was determined that the dTDP-rhamnose synthesis gene, rmlD , could be inactivated in Mycobacterium smegmatis only in the presence of a rescue plasmid carrying functional rmlD. Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.

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