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Effects of Cyproterone Acetate (CPA) on Pituitary Gonadotrophin Release and on Androgen Secretion Before and After LH‐RH Double Stimulation Tests in Men

1978; Wiley; Volume: 1; Issue: s2b Linguagem: Inglês

10.1111/j.1365-2605.1978.tb00518.x

2047-2927

L. Moltz, A. Römmler, U. Schwartz, J. Hammerstein,

Sperm and Testicular Function

CPA administration at a medium dosage of 10 mg daily for male fertility control resulted in reduced spermiograms and in a distinct decrease in basal T (70% reduction), DHT (50%), LH (30%) and FSH (40%). The episodic fluctuations in gonadotrophin secretion were not affected, but the spiking phenomenon of androgen secretion was completely abolished. Pituitary responses to LH‐RH were reduced significantly for both LH and FSH. Also the gradual increase of T and DHT in the course of the LH‐RH double stimulation tests was reduced. It is concluded that the progestational/antigonadotrophic action of CPA predominates over the antiandrogenic action. In addition, a direct effect at the testicular level is postulated.