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Validation of Arteriograph – A New Oscillometric Device to Measure Arterial Stiffness in Patients on Maintenance Hemodialysis

2009; Karger Publishers; Volume: 32; Issue: 3 Linguagem: Inglês

10.1159/000228935

1423-0143

János Nemcsik, J. Egresits, Taha El Hadj Othmane, Bertalan Csaba Fekete, Erzsébet Fodor, Tamás Szabó, Zoltán Járai, Csaba Jekkel, István Kiss, András Tislér,

Dialysis and Renal Disease Management

<i>Background:</i> Measuring arterial stiffness (augmentation index (AI), aortic pulse wave velocity (PWV)) in hemodialysis (HD) patients has prognostic significance. To assess its validity, the new oscillometric Arteriograph device (AI_A, PWV_A) was compared to the validated PulsePen tonometer (AI_P, PWV_P). <i>Methods:</i> AI and PWV were measured in 98 patients with both devices before HD. Validity was evaluated by Pearson’s correlation, Bland-Altman analysis, and by assessing the prognostic value of AI and PWV to predict cardiovascular (CV) mortality over 29 months. <i>Results:</i> Correlation between AI_P and AI_A was significant (R = 0.527, p < 0.001). The mean difference of AI values obtained by the two devices was –20.6%, and 30% of the paired AI differences fall outside the ±1 SD boundary of the mean between-device difference. There was no significant correlation between the PWV_P and PWV_A readings (R = 0.173, p = 0.097). The average difference of PWV values by the two devices was –1.2 m/s, and 20.6% of the paired PWV differences fall outside the ±1 SD boundary. In survival analyses, only PWV_P but not PWV_A was significantly related to CV mortality. <i>Conclusion:</i> Lack of correlation between PWV_P and PWV_A and lack of prognostic significance of PWV_A suggest limited validity of Arteriograph to determine PWV in patients on HD.