Tunable Carbon−Carbon and Carbon−Sulfur Cross-Coupling of Boronic Acids with 3,4-Dihydropyrimidine-2-thiones
2004; American Chemical Society; Volume: 6; Issue: 5 Linguagem: Inglês
10.1021/ol036496h
ISSN1523-7060
AutoresAlenka Lengar, C. Oliver Kappe,
Tópico(s)Multicomponent Synthesis of Heterocycles
ResumoDirect microwave-assisted Pd(0)-catalyzed/Cu(I)-mediated carbon−carbon cross-coupling of 3,4-dihydropyrimidine-2-thiones and boronic acids under Liebeskind−Srogl conditions leads to 2-aryl-1,4-dihydropyrimidines in moderate to high yield. In contrast, Cu(II)-mediated reaction of the same substrates leads to carbon−sulfur cross-coupling.
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