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A COMPARISON OF THE RESISTANCE OF MALE AND FEMALE RATS TO CORTIN¹

1939; Oxford University Press; Volume: 24; Issue: 2 Linguagem: Inglês

10.1210/endo-24-2-194

1945-7170

Dwight J. Ingle, R Minnesota,

Stress Responses and Cortisol

WHEN LARGR AMOUNTS of cortin are administered to normal male rats Wthere occur atrophy of the adrenal cortices, atrophy of theHEN LARGE AMOUNTSthymus, cessation of body growth and loss of general body weight (i). In the present experiment male and female rats are compared in respect to their resistance t o large amounts of cortin. All of the rats used in this experiment had an initial body weight of 180 gm. Thirty male rats and 22 female rats were killed at this body weight in order to obtain control data on the weights of the adrenals and of the thymus. Thirty male rats and 32 female rats were treated for 1 week with varying amounts of cortin, which was administered in the drinking water. The choice of this method of administering cortin was based on previous comparisons (1, 2) of the drinking water method with the daily injection method in respect to its effects on the cortico'adrenal tissue of normal rats.