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Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides

2014; Springer Nature; Volume: 35; Issue: 3 Linguagem: Inglês

10.1038/aps.2013.155

1745-7254

Jing Xu, Cheng‐Shi Jiang, Zailong Zhang, Wenquan Ma, Yue‐Wei Guo,

Microbial Natural Products and Biosynthesis

Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti-tumor, anti-bacteria, and anti-malaria activities, etc. This review summarizes progress in isolation, bioactivity studies, biosynthesis, and representative chemical syntheses of this group of macrolides in recent decades, encompassing 63 naturally occurring macrolides published in 120 articles.