The Effects of Charcoal and Sorbitol (Alone and in Combination) on Plasma Theophylline Concentrations after a Sustained-Release Formulation
1990; SAGE Publishing; Volume: 9; Issue: 3 Linguagem: Inglês
10.1177/096032719000900310
ISSN1477-0903
AutoresAbdullah Alshareef, D. C. Buss, Elizabeth Allen, PA Routledge,
Tópico(s)Drug-Induced Hepatotoxicity and Protection
Resumo1 The effects of charcoal and sorbitol, alone and in combination, were investigated in eight healthy female volunteers who received 600 mg slow-release theophylline (two 300 mg capsules) . 2 The area under the plasma concentration time curve to 24 h (AUC 0-24 ) after theophylline alone was significantly greater than after both the charcoal and charcoal plus sorbitol phase. 3 Charcoal and charcoal with sorbitol also significantly reduced the maximum plasma theophylline concentration ( T max ) and time to maximum concentration ( C max ). 4 Sorbitol significantly increased C max and shortened T max . 5 Although sorbitol did not reduce the adsorptive efficacy of charcoal, its use alone may be deleterious in poisoning with sustained-release theophylline products.
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