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Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects

1999; Springer Nature; Volume: 13; Issue: 5 Linguagem: Inglês

10.1038/eye.1999.178

1476-5454

Osman Çekıç, Coşar Batman, Yüksel Totan, Ümit Yaşar, Nursabah E. Başcı, Atilla Bozkurt, S.O. Kayaalp, Orhan Zilelioğlu,

Ocular Diseases and Behçet’s Syndrome

Purpose To evaluate aqueous humour levels of topical 0.3% ciprofloxacin and 0.3% ofloxacin in the same subjects. Methods Thirty-two bilateral cataractous patients received topical 0.3% ciprofloxacin in one eye and 0.3% ofloxacin in the other eye before each cataract extraction. Eyedrops were repetitively instilled for 6 h. Aqueous humour samples were collected and assayed for drug concentrations by a method described originally by us using high-performance liquid chromatography. Results Mean aqueous ciprofloxacin and ofloxacin levels were 0.33 ± 0.04 μg/ml (mean ± SEM) and 1.34 ± 0.14 μg/ml respectively (p<0.0001). Conclusion Ofloxacin level in the aqueous humour is 4 times higher than that of ciprofloxacin in the same subjects.