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Usefulness of Taurine in Chronic Congestive Heart Failure and Its Prospective Application.

1992; Japanese Circulation Society; Volume: 56; Issue: 1 Linguagem: Inglês

10.1253/jcj.56.95

1347-4839

Junichi Azuma, Akihiko Sawamura, Nobuhisa Awata,

Biochemical Acid Research Studies

We compared the effect of oral administration of taurine (3g/day) and coenzyme Q10 (CoQ ) (30 mg/day) in 17 patients with congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy, whose ejection fraction assessed by echocardiography was less than 50%. The changes in echo-cardiographic parameters produced by 6 weeks of treatment were evaluated in a double-blind fashion. In the taurine-treated group significant treatment effect was observed on systolic left ventricular function after 6 weeks. Such an effect was not observed in the CoQ10-treated group.