Portal de Periódicos da CAPES

Characterization of a t(8;13)(p11;q11-12) in an atypical myeloproliferative disorder

1998; Wiley; Volume: 21; Issue: 1 Linguagem: Inglês

10.1002/(sici)1098-2264(199801)21

1098-2264

Damian Smedley, Gino R. Somers, Deon J. Venter, C.W. Chow, Colin S. Cooper, Janet Shipley,

Acute Myeloid Leukemia Research

Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11-12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yeast artificial chromosomes (YACs) derived from the 8p11 and 13q11-12 regions to analyse one of the t(8;13) cases by fluorescence in situ hybridization (FISH). YACs flanking the 13q11-12 breakpoint and spanning the 8p11 breakpoint have been isolated. These YACs will facilitate characterization of the genes involved in this rearrangement. Genes Chromosomes Cancer 21:70–73, 1998. © 1998 Wiley-Liss, Inc.