Vitamin E
2005; Lippincott Williams & Wilkins; Volume: 31; Issue: s1 Linguagem: Inglês
10.1111/j.1524-4725.2005.31724
ISSN1524-4725
AutoresJens J. Thiele, Sherry N. Hsieh, Swarna Ekanayake‐Mudiyanselage,
Tópico(s)Bee Products Chemical Analysis
ResumoBackground and Objective. The lipophilic antioxidant vitamin E has been used for more than 50 years in clinical and experimental dermatology. However, although a large number of case reports were published, there is still a lack of controlled clinical studies providing a rationale for clinical indications and dosage. In contrast, advances in basic research on the physiology, mechanism of action, penetration, bioconversion, and photoprotection of vitamin E in human skin have led to the development of numerous new formulations for use in cosmetics and skin care products. Results. This article reviews the basic mechanisms and possible cosmetical and clinical implications of the recent advances in cutaneous vitamin E research. Experimental evidence suggests that topical and oral vitamin E has anticarcinogenic, photoprotective, and skin barrier–stabilizing properties. Conclusion. Although its current use is largely limited to cosmetics, controlled clinical studies for indications such as atopic dermatitis or prevention of photocarcinogenesis are needed to evaluate the clinical benefit of vitamin E. JENS J. THIELE, MD, SHERRY N. HSIEH, PHD, AND SWARNA EKANAYAKE-MUDIYANSELAGE, MD, HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.
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