Is Treatment of Hemorrhagic Radiation Cystitis with Hyperbaric Oxygen Effective?
2010; Karger Publishers; Volume: 84; Issue: 4 Linguagem: Inglês
10.1159/000296289
ISSN1423-0399
AutoresBadereddin Mohamad Al–Ali, Harald Trummer, Rany Shamloul, Richard Zigeuner, Karl Pummer,
Tópico(s)Urological Disorders and Treatments
Resumo<i>Objective:</i> We report our own experience with the use of hyperbaric oxygen (HBO) for the management of postradiation hemorrhagic cystitis. <i>Methods:</i> We reviewed retrospectively 14 patients from 2001 to 2007 with different pelvic organ malignancies who developed radiation cystitis after irradiation. Patients received 100% oxygen in a hyperbaric chamber at a pressure of 2.5 atmospheres absolute, 60 min bottom time, once a day, 7 days a week for at least 1 month. In principle, 30 HBO treatments per course were performed. After every course of HBO treatments, therapeutic effect was evaluated. The mean duration of follow-up of all patients was 18 months (range: 1–6 years). <i>Results:</i> Patients were divided into 2 groups, group 1 (treatment group, n = 10) and group 2 (without treatment, n = 4). The mean duration between the onset of hematuria and the beginning of HBO therapy was 8.9 months (range: 3–34). Group 2 did not receive HBO because they were not healthy enough. Only 2 patients (20%) of group 1 recovered from their hemorrhagic cystitis. Group 1 had a significantly lower cure rate of postirradiation hemorrhagic cystitis in comparison to group 2. <i>Conclusions:</i> Our experience with the use of HBO did not yield favorable results. Randomized well-controlled studies are needed.
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