Cucubalactam and Brachystemin E, Two New Compounds from Caryophyllaceae
2001; Elsevier BV; Volume: 55; Issue: 10 Linguagem: Inglês
10.3987/com-01-9276
ISSN1881-0942
AutoresJun Zhou, Yong‐Xian Cheng, Ning‐Hua Tan, Lu Yang, Xuying Liu, Qi‐Tai Zheng,
Tópico(s)Phytochemical Studies and Bioactivities
ResumoA new pyrrolidone peroxide, named cucubalactam (1), and a new octacyclopeptide, named brachystemin E (2), have been isolated from Caryophyllaceae plants, Cucubalus baccifer and Brachystemma calycinum, respectively.Their structures were determined by spectral methods, especially by 1D and 2D NMR techniques.The stereochemistry of compound (2) was demonstrated by X-Ray crystallograph.Caryophyllaceae family covers about 70 genera and about 1750 species, it is distributed world-wide especially in temperate and frigid zones.Many plants in this family such as Pseudostellaria heterophylla, Vaccaria segetalis, Dianthus superbus, Psammosilene tunicoides are famous Chinese materia medica.In the past, the chemical investigations on this family focused on saponins, 1 flavonoids, 2 and phytoecdysterones. 37][8][9] We investigated two Caryophyllaceae plants, Cucubalus baccifer and Brachystemma calycinum, the former has been used for pulmonary tuberculosis and scrofula, 10 and the latter used for rheumatism, limb numbness, impotence and feet edema in China. 11From the EtOAc extracts of them, two new compounds, cucubalactam (1) and brachystemin E (2), were isolated using ninhydrin as coloring reagent.We here reported their isolation and structural elucidation.
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