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Tumor location is a prognostic factor for survival of Chinese women with T1-2N0M0 breast cancer

2014; Wolters Kluwer; Volume: 12; Issue: 5 Linguagem: Inglês

10.1016/j.ijsu.2014.03.011

1743-9191

San‐Gang Wu, Juan Zhou, Yufeng Ren, Jiayuan Sun, Feng‐Yan Li, Qin Lin, Huan‐Xin Lin, Zhen‐Yu He,

Cancer Genomics and Diagnostics

The purpose of this study was to investigate the effects of primary tumor location on the survival of Chinese women with T1-2N0M0 breast cancer.The clinical data of 1044 patients with stage T1-2N0M0 breast cancer who were treated from 1999 to 2007 were retrospectively analyzed. Patients were divided according to the primary tumor location: upper-outer quadrant (UOQ), upper-inner quadrant (UIQ), lower-outer quadrant (LOQ), lower-inner quadrant (LIQ), and nipple and central breast (central). The effect of primary tumor location on recurrence-free survival (RFS) and overall survival (OS) were determined.The median age at diagnosis was 47 years. The tumor was located in the UOQ in 524 patients (50.2%), the LOQ in 124 (11.9%), the UIQ in 229 (21.9%), the LIQ in 59 (5.7%), and centrally in 108 patients (10.3%). The 5- and 10-year RFS and OS of the LIQ group were significantly poorer than that of patients in the other groups (RFS: 72.1% vs. 82.2-86.7%, P = 0.041; OS: 73.6% vs. 85.3-89.1%, P = 0.024). Multivariate Cox analysis showed that primary tumor location in the LIQ was an independent prognostic factor for RFS (hazard ratio [HR] = 2.977; 95% confidence interval [CI] 1.219-7.273; P = 0.017) and OS (HR = 2.949; 95% CI 1.207-7.208; P = 0.018).Primary tumor location is an important prognostic factor for survival of Chinese women with T1-2N0M0 breast cancer.