Histoplasmosis diseminada y sida en un hospital argentino: manifestaciones clínicas, diagnóstico y tratamiento
2004; Elsevier BV; Volume: 22; Issue: 3 Linguagem: Inglês
10.1016/s0213-005x(04)73056-6
ISSN1695-4114
AutoresDiego Pietrobon, Liliana Negro-Marquínez, Jorge Kilstein, Jorge Galíndez, Alcides Greca, Carlos Battagliotti,
Tópico(s)Nail Diseases and Treatments
ResumoWe describe 16 HIV-infected patients with disseminated histoplasmosis (14 men, mean age 28 +/- 7.84 years), diagnosed at Hospital Eva Perón in Argentina during the period of October 1993 to July 2000. Disseminated histoplasmosis occurred in 5.3% of HIV-infected patients over the study period. The main symptoms included fever, weight loss and hepatosplenomegaly in 93.8%. Other relevant findings were respiratory compromise (56.3%), digestive symptoms (43.8%), mucocutaneous lesions (75%) and multiple lymphadenopathy (69%). Treatment consisted of amphotericin B 1 mg/kg/day up to a total dose of 1 g, followed by 400 mg/day of oral itraconazole. Mortality in the acute phase was 19% and 37.5% of patients relapsed.
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