Sprinting without myostatin: a genetic determinant of athletic prowess
2007; Elsevier BV; Volume: 23; Issue: 10 Linguagem: Inglês
10.1016/j.tig.2007.08.008
ISSN1362-4555
Autores Tópico(s)Cardiomyopathy and Myosin Studies
ResumoGenetic studies in several species have demonstrated that myostatin (MSTN) normally functions to limit skeletal muscle mass. In a recent study, Mosher et al. reported that a mutation in the canine MSTN gene is responsible for the double-muscling phenotype seen in 'bully' whippets. Furthermore, they show that loss of even one functional MSTN allele seems to confer a competitive advantage to racing whippets, providing the first definitive evidence that loss of myostatin function can enhance athletic performance.
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